Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

TMT-based quantitative proteomics of young and old cynomolgus monkey heart

ABSTRACT: TMT-based quantitative proteomics of young and old cynomolgus monkey heart.

ORGANISM(S): Macaca Fascicularis

SUBMITTER: Weiqi Zhang

PROVIDER: PXD036689 | iProX | Tue Sep 13 00:00:00 BST 2022

REPOSITORIES: iProX

ACCESS DATA

Json Xml

Similar Datasets

TMT isobaric profiling of young versus old haematopoietic stem cells

Project description:Mass spectrometry was performed with an Orbitrap Fusion Tribrid mass spectrometer (Thermo Scientific) interfaced with an UltiMate 3000 Binary RSLCnano System (Dionex). Proteome Discoverer v.1.4 (Thermo Scientific) with SEQUEST HT search engines was used for the spectra-preprocessing and HCD MS2 spectra were used for peptide identification and quantitation based on TMT reporter ions. TMT isobaric comparison of old versus young haematopoietic stem and progenitor cells. Young 1 and Young 2 are samples 126 and 128 of dataset UTH_1. Old 1 and Old 2 are samples 129 and 130 of UTH_1. Young 3 is sample 131 and Old 3 is sample 130 of dataset UTH_4.

2023-10-16 | MSV000093126 | MassIVE

Proteomics of young and old skeletal muscle tissue in cynomolgus monkeys

Project description:Proteomics of young and old skeletal muscle tissue in cynomolgus monkeys

2024-06-07 | PXD052984 |

Differences in heart gene expression between aging and young mice

Project description:The study of gene expression in aging heart is necessary for the study of heart disease. We raised old mice and young mice to detect gene expression differences in the heart by RNA-seq.

2025-03-22 | GSE292148 | GEO

mRNA expression of young, mid-old, and old fibroblasts

Project description:mRNA expression of young, mid-old, and old fibroblasts

| PRJNA971965 | ENA

mRNA expression of young, mid-old, and old fibroblasts

Project description:Examination of the difference in mRNA expression profile between young, mid-old, and old fibroblasts

2023-05-19 | GSE232427 | GEO

RNA sequencing of young and old lung ILC2 cells

Project description:ILC2 cells from young and old mouse lungs were analysed and revealed altered transcriptome of old ILC2 compared to the young.

2022-01-23 | GSE125584 | GEO

TMT-Based Quantitative Proteomics of Cerebrospinal Fluid Reveals Molecular Signatures of Lymphatic Drainage Impairment in Young Rats

Project description:The glymphatic system facilitates the clearance of interstitial solutes and waste products from the brain parenchyma, channeling them into the meningeal lymphatic vessels for subsequent drainage into the deep cervical lymph nodes (dcLNs). However, the extent to which this lymphatic outflow via dcLNs is essential for maintaining cerebral homeostasis remains insufficiently understood. To address this, we performed high-resolution proteomic profiling of cerebrospinal fluid (CSF) from 3-month-old rats using Tandem Mass Tag (TMT)–based quantitative mass spectrometry. This approach enabled the sensitive detection of proteomic perturbations in the CSF resulting from impaired lymphatic drainage. A total of six CSF samples from 3-month-old rats (n=6) were analyzed. TMT 10-plex–based quantitative proteomics revealed 4,089 proteins, among which 357 exhibited statistically significant differential expression (p < 0.05). These proteomic alterations indicated early signs of cellular stress and low-grade inflammation. Pathway enrichment analysis further revealed upregulation of molecular cascades associated with neurodegenerative processes, even in this relatively young cohort, following lymphatic disruption.

2025-07-04 | PXD063564 | Pride

Expression Analysis of Trimethyltin Chlorides (TMT) Impact on Embryonic Development

Project description:Investigation of whole genome expression pattern of 60 and 72 hours post fertilization Danio Rerio embryos exposed to TMT and vehicle control Embryos were exposed to 10uM TMT or control from 48hpf to 60 or 72 hpf. Three replicates were collected for each time point. 40 embryos were pooled to comprise a replicate.

2011-03-23 | E-GEOD-28131 | biostudies-arrayexpress

Gene expression in young and old pituitary

Project description:Gene expression in young and old pituitary

| PRJNA888784 | ENA

ATACseq for Young and Old mouse liver

Project description:ATACseq for Young and Old mouse liver

| PRJNA1019283 | ENA