Liver proteomic reveals the key proteins involved in host immune response to sepsis

ABSTRACT: Sepsis is a serious infection-induced response in the host,which can lead to organ dysfunction. It is of great importance to unravel the relationship between sepsis and host immune response and its mechanisms of action. Liver is one of the most vulnerable organs in sepsis, however, the specific pathogenesis of septic liver injury has not been well understood at the protein level. Here, a TMT-based proteomic analysis for liver was performed in the septic rat model. Compared to the healthy control group,the differentially expressed proteins (DEPs) were the most significantly enriched into the complement and coagulation cascades and metabolic pathways. And the DEPs may serve as clinically potential treatment targets for septic liver injury.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Dixian Luo  

PROVIDER: PXD037868 | iProX | Tue Nov 15 00:00:00 GMT 2022

REPOSITORIES: iProX