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Whole blood transcriptomic profiling identifies expression signatures for sepsis mortality

ABSTRACT: Sepsis is the leading cause of death in U.S. hospitals and affects nearly 50 million people globally per year. Sepsis is defined as the ‘dysregulated host response to infection’, however, identifying specific and targetable immune abnormalities for therapeutic intervention has been challenging. An effective immune response clears pathogen but also protects host tissues from collateral damage. In sepsis, however, broad immune dysregulation causes organ failure and increased risk of mortality. Therapeutic trials targeting known inflammatory markers in sepsis have failed to improve outcomes. Efforts to identify sepsis therapies may have been thwarted by a focus on the wrong targets, undetected or unaccounted-for heterogeneity among study participants, or issues of timing in a highly dynamic immune response and clinical syndrome. Analysis of the leukocyte transcriptome can reveal elements of the dysregulated host response to infection that characterizes sepsis. We hypothesized that sepsis nonsurvivors have a distinct transcriptional signature, and we thus sought to identify, validate, and contextualize the whole blood transcriptomic changes associated with sepsis mortality in patients with and without septic shock.

ORGANISM(S): Homo sapiens

PROVIDER: GSE272769 | GEO | 2025/11/03

REPOSITORIES: GEO

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