Dataset Information
MS analysis of endogenously precipitated DDX20 protein complexes (immunoprecipitation (IP)–MS)
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens Mus Musculus
SUBMITTER: 
Wei Song
PROVIDER: PXD038171 | iProX | Wed Apr 24 00:00:00 BST 2024
REPOSITORIES: iProX
Publications
DDX20 is required for cell-cycle reentry of prospermatogonia and establishment of spermatogonial stem cell pool during testicular development in mice.
Developmental cell 20240423 13
RNA-binding proteins (RBPs), as key regulators of mRNA fate, are abundantly expressed in the testis. However, RBPs associated with human male infertility remain largely unknown. Through bioinformatic analyses, we identified 62 such RBPs, including an evolutionarily conserved RBP, DEAD-box helicase 20 (DDX20). Male germ-cell-specific inactivation of Ddx20 at E15.5 caused T1-propsermatogonia (T1-ProSG) to fail to reenter cell cycle during the first week of testicular development in mice. Consequen ...[more]
