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Exosomal proteins identification from neonatal mouse plasma

ABSTRACT: Paracrine effects mediated by exosomes contribute to the major regenerative functions of cell therapies after myocardial injuries. Early neonatal mammals retain a transient regeneration capacity after heart injury, which reminds us to explore the cardioprotective and regenerative potency of plasma exosomes from neonatal mouse (npEXO). Therefore, we isolated plasma exosomes from neonatal mice and performed proteomic analysis.

ORGANISM(S): Mus Musculus

SUBMITTER: Xudong Guo

PROVIDER: PXD038805 | iProX | Tue Dec 13 00:00:00 GMT 2022

REPOSITORIES: iProX

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Neonatal Plasma Exosomes Contribute to Endothelial Cell-Mediated Angiogenesis and Cardiac Repair after Acute Myocardial Infarction.

Li Xiuya X Lian Yilin Y Wu Yukang Y Ye Zihui Z Feng Jiabao J Zhao Yuan Y Guo Xudong X Kang Jiuhong J

International journal of molecular sciences 20230206 4

Acute myocardial infarction (AMI) accompanied by cardiac remodeling still lacks effective treatment to date. Accumulated evidences suggest that exosomes from various sources play a cardioprotective and regenerative role in heart repair, but their effects and mechanisms remain intricate. Here, we found that intramyocardial delivery of plasma exosomes from neonatal mice (npEXO) could help to repair the adult heart in structure and function after AMI. In-depth proteome and single-cell transcriptome ...[more]

PMID: 36834610

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