Dendrobium mixture ameliorates non-alcoholic fatty liver disease induced by type 2 diabetes mellitus through PPAR gamma: an integrated study of bioinformatics analysis and experimental verification

ABSTRACT: Dendrobium mixture (DM) is a patented Chinese herbal medicine indicated which has anti inflammatory and improved glycolipid metabolism. However, its active ingredients, targets of action, and potential mechanisms are still uncertain. Here, we investigate the role of DM as a prospective modulator of protection against nonalcoholic fatty liver disease (NAFLD) induced by type 2 diabetes mellitus (T2DM) and illustrate the molecular mechanisms potentially involved. The network pharmacology and TMT-based quantitative protomics analysis were conducted to identify potential gene targets of the active ingredients in DM against NAFLD and T2DM. DM was administered to the mice of DM group for 4 weeks, and db/m mice (control group) and db/db mice (model group) were gavaged by normal saline.Besides, db/db mice(Metformin group) were gavaged by Metformin.

ORGANISM(S): Mus Musculus

SUBMITTER: Hong Shi  

PROVIDER: PXD039727 | iProX | Sat Jan 28 00:00:00 GMT 2023

REPOSITORIES: iProX