Deacetylation Induced Nuclear Condensation of HP1γ Promotes Multiple Myeloma Drug Resistance

ABSTRACT: Functional crosstalk between histone modifications and chromatin remodeling has emerged as a key regulatory mode of transcriptional control during drug resistance, but the underlying mechanisms are not fully understood. Here we demonstrate that different proteins and their acetylation modification regulate the resistance of multiple myeloma cells to BTZ.

ORGANISM(S): Homo Sapiens

SUBMITTER: Zhiqiang Liu  

PROVIDER: PXD040298 | iProX | Mon Feb 20 00:00:00 GMT 2023

REPOSITORIES: iProX