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Proteome alteration of envenomed muscle in mice and the antidotal effect of a novel metalloproteinase inhibitor from Sinonatrix annularis

ABSTRACT: Snakebite by Deinagkistrodon acutus often leads to severe tissue necrosis, hemorrhage and inflammation due to the high content of metalloproteinase (SVMP) and phospholipase A2 (PLA2). These impairments can be significantly alleviated by serum of Sinonatrix annularis, a nonvenomous snake endogenous in China. Here, the proteome alteration of envenomed mice were determined using TMT labeling technique to clarify the mechanism of D. acutus envenomation and S. annularis protection.

ORGANISM(S): Mus <genus>

SUBMITTER: Chunhong Huang

PROVIDER: PXD040300 | iProX | Tue Feb 21 00:00:00 GMT 2023

REPOSITORIES: iProX

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