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Astrocyte-microglia interaction drives Aβ induced initial memory deficit

ABSTRACT: Based on behavioral paradigms, olfactory memory impaiment was considered as the first congnitive decline symptom in 5xFAD mice at 4-month-old. Proteomes in olfactory memory associated brain region, piriform cortex, at different stages were analyzed. The results indiciated that proteins alterations at different stages are diverse, but the core regulatory network involved in AD pathogenesis is conservd. Microglia and astrocyte specific proteins are enriched in the networks and associated with glial cell activation in the initial cognitive impairment stage. It implied the mutual effect of the two glial cells plays an essential role in Aβ induced initial AD pathogenesis.

ORGANISM(S): Mus Musculus

SUBMITTER: Kefu Liu

PROVIDER: PXD040802 | iProX | Mon Mar 13 00:00:00 GMT 2023

REPOSITORIES: iProX

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The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer's disease.

Liu Kefu K Aierken Ailikemu A Liu Mengyao M Parhat Nazakat N Kong Wei W Yin Xingyu X Liu Gang G Yu Ding D Hong Jie J Ni Junjun J Quan Zhenzhen Z Liu Xiaoyun X Ji Simei S Mao Jian J Peng Weijun W Chen Chao C Yan Yan Y Qing Hong H

iScience 20240220 3

Alzheimer's disease (AD) is the most common neurodegenerative disease often associated with olfactory dysfunction. Aβ is a typical AD hall marker, but Aβ-induced molecular alterations in olfactory memory remain unclear. In this study, we used a 5xFAD mouse model to investigate Aβ-induced olfactory changes. Results showed that 4-month-old 5xFAD have olfactory memory impairment accompanied by piriform cortex neuron activity decline and no sound or working memory impairment. In addition, synapse an ...[more]

PMID: 38455972

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