Proteomics

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Global quantitative analysis of proteomic of mice with liver fibrosis based on DIA and PRM technology

ABSTRACT: Liver fibrosis (LF) is a kind of progressive liver injury reaction. The goal of this study was to achieve a more detailed understanding of the molecular changes in response to CCl4-induced LF through the identification of a differentially expressed liver proteomic. A total of 302 differentially expressed proteins (DEPs) were significantly identified at the proteomic level. Importantly,Gstm1, Gstm3, Ephx1 and Gstp1 were shown to be associated with metabolic pathways, and parallel reaction monitoring (PRM) verification showed that the results were consistent with those of data -independent acquisition (DIA). Through the analysis of proteomic data, this study provides valuable insights into the potential mechanism of the pathogenesis of LF, and lays a theoretical foundation for the further development of targeted therapy for LF.

ORGANISM(S): Mus Musculus

SUBMITTER: Hui Jiang  

PROVIDER: PXD040876 | iProX | Tue Mar 14 00:00:00 GMT 2023

REPOSITORIES: iProX

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Liver transcriptomic and proteomic analyses provide new insight into the pathogenesis of liver fibrosis in mice.

Zhang Lili L   Zhou Qiumei Q   Zhang Jiafu J   Cao Kefeng K   Fan Chang C   Chen Sen S   Jiang Hui H   Wu Furong F  

Genomics 20231031 6

<h4>Background</h4>Liver fibrosis (LF) is a kind of progressive liver injury reaction. The goal of this study was to achieve a more detailed understanding of the molecular changes in response to CCl<sub>4</sub>-induced LF through the identification of a differentially expressed liver transcriptomic and proteomic.<h4>Results</h4>A total of 1224 differentially expressed genes (DEGs) and 302 differentially expressed proteins (DEPs) were significantly identified at the transcriptomic and proteomic l  ...[more]

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