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Proteome profiling of colorectal cancer-infiltrating T cells to screen key regulators of CRC progression.

ABSTRACT: Using a tandem mass tag (TMT)-based quantitative proteomic study, we described the protein expression pattern of colorectal cancer-infiltrating T cells, revealed T cell dysfunctions in CRC, screened key regulator of CRC progression.

ORGANISM(S): Homo Sapiens

SUBMITTER: Jianguo Ji

PROVIDER: PXD041366 | iProX | Thu Apr 06 00:00:00 BST 2023

REPOSITORIES: iProX

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Quantitative Proteomics of Tissue-Infiltrating T Cells From CRC Patients Identified Lipocalin-2 Induces T-Cell Apoptosis and Promotes Tumor Cell Proliferation by Iron Efflux.

Che Rui R Wang Qingsong Q Li Minzhe M Shen Jian J Ji Jianguo J

Molecular & cellular proteomics : MCP 20231210 1

T cells play the most pivotal roles in antitumor immunity; the T-cell proteome and the differentially expressed proteins in the tumor immune microenvironment have rarely been identified directly from the clinical samples, especially for tumors that lack effective immunotherapy targets, such as colorectal cancer (CRC). In this study, we analyzed the protein expression pattern of the infiltrating T cells isolated from CRC patients using quantitative proteomics. CD4<sup>+</sup> and CD8<sup>+</sup> ...[more]

PMID: 38072118

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