Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Xingchao Shentu
PROVIDER: PXD041436 | iProX | Mon Apr 10 00:00:00 BST 2023
REPOSITORIES: iProX
Huang Yuxin Y Ping Xiyuan X Cui Yilei Y Yang Hao H Bao Jing J Yin Qichuan Q Ailifeire Hailaiti H Shentu Xingchao X
Antioxidants (Basel, Switzerland) 20230619 6
Hypoxic environments are known to trigger pathological damage in multiple cellular subtypes. Interestingly, the lens is a naturally hypoxic tissue, with glycolysis serving as its main source of energy. Hypoxia is essential for maintaining the long-term transparency of the lens in addition to avoiding nuclear cataracts. Herein, we explore the complex mechanisms by which lens epithelial cells adapt to hypoxic conditions while maintaining their normal growth and metabolic activity. Our data show th ...[more]