Proteomics

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Characterization of kidney-specific and site-specific N-glycosylation signatures of isolated uromodulin from human urine

ABSTRACT: Uromodulin (Umod, Tamm–Horsfall protein), as the most abundant urinary N-glycoprotein exclusively produced by the kidney, can form filaments to antagonize the adhesion of uropathogens. However, the kidney-specific and site-specific N-glycosylation signatures of this glycoprotein remain poorly understood due to the lack of suitable isolated and analytical methods.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yong Zhang  

PROVIDER: PXD041640 | iProX | Thu May 11 00:00:00 BST 2023

REPOSITORIES: iProX

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Uromodulin (Umod, Tamm-Horsfall protein) is the most abundant urinary <i>N</i>-glycoprotein produced exclusively by the kidney. It can form filaments to antagonize the adhesion of uropathogens. However, the site-specific <i>N</i>-glycosylation signatures of Umod in healthy individuals and patients with IgA nephropathy (IgAN) remain poorly understood due to the lack of suitable isolation and analytical methods. In this study, we first presented a simple and fast method based on diatomaceous earth  ...[more]