Ontology highlight
ABSTRACT:
INSTRUMENT(S): 6520 Quadrupole Time-of-Flight LC/MS
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Skeletal Muscle
SUBMITTER: Jordy Hsiao
LAB HEAD: Michael Eugene Wright
PROVIDER: PXD004020 | Pride | 2016-04-22
REPOSITORIES: Pride
Molecular & cellular proteomics : MCP 20160420 6
Mutations in genes encoding components of the sarcolemmal dystrophin-glycoprotein complex (DGC) are responsible for a large number of muscular dystrophies. As such, molecular dissection of the DGC is expected to both reveal pathological mechanisms, and provides a biological framework for validating new DGC components. Establishment of the molecular composition of plasma-membrane protein complexes has been hampered by a lack of suitable biochemical approaches. Here we present an analytical workfl ...[more]