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AK9 causes asthenozoospermia and male infertility

ABSTRACT: Deficiency in AK9 causes asthenozoospermia and male infertility by destabilizing sperm nucleotide homeostasis

ORGANISM(S): Homo Sapiens

SUBMITTER: Yanwei Sha

PROVIDER: PXD043689 | iProX | Tue Jul 11 00:00:00 BST 2023

REPOSITORIES: iProX

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Deficiency in AK9 causes asthenozoospermia and male infertility by destabilising sperm nucleotide homeostasis.

Sha Yanwei Y Liu Wensheng W Li Shu S Osadchuk Ludmila V LV Chen Yongjie Y Nie Hua H Gao Shuai S Xie Linna L Qin Weibing W Zhou Huiliang H Li Lin L

EBioMedicine 20230913

<h4>Background</h4>Asthenozoospermia is the primary cause of male infertility; however, its genetic aetiology remains poorly understood. Adenylate kinase 9 (AK9) is highly expressed in the testes of humans and mice and encodes a type of adenosine kinase that is functionally involved in cellular nucleotide homeostasis and energy metabolism. We aimed to assess whether AK9 is involved in asthenozoospermia.<h4>Methods</h4>One-hundred-and-sixty-five Chinese men with idiopathic asthenozoospermia were ...[more]

PMID: 37713809

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