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Proteomic study of Selinexor alleviating bleomycin-induced pulmonary fibrosis

ABSTRACT: Selinexor is an orally bioavailable, small-molecule selective inhibitor of nuclear export protein that has been approved for the clinical treatment of relapsed or refractory multiple myeloma. At present, some studies have found that Selinexor can play an anti-inflammatory role in sepsis. We found that Selinexor, a selective inhibitor of XPO1, can alleviate bleomycin-induced pulmonary fibrosis in mice in our research work, but the specific mechanism is still unclear. After Selinexor treatment of bleomycin-induced pulmonary fibrosis in mice, we detected some differentially expressed proteins through proteomics, which may be the key mechanism of alleviating pulmonary fibrosis.

ORGANISM(S): Mus Musculus

SUBMITTER: Jia Zhang

PROVIDER: PXD044259 | iProX | Tue Aug 01 00:00:00 BST 2023

REPOSITORIES: iProX

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