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Co-analysis of serum and urine differentially expressed proteins in mucopolysaccharidosis type I

ABSTRACT: Identify the differential protein profile in serum and urine of MPS I patients using the TMT technique and verfied by PRM technique.

ORGANISM(S): Homo Sapiens

SUBMITTER: Jinyan Duan

PROVIDER: PXD044716 | iProX | Tue Aug 22 00:00:00 BST 2023

REPOSITORIES: iProX

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Co-Analysis of Serum and Urine Differentially Expressed Proteins in Mucopolysaccharidosis Type I.

Liu Kefu K Wan Gefan G Li Yongcong Y Liang Zhenlong Z Meng Yan Y Yuan Xiaozhou X Duan Jinyan J

Journal of proteome research 20240102 2

Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disease caused by the deficiency of the enzyme α-l-iduronidase (IDUA), typically leading to devastating secondary pathophysiological cascades. Due to the irreversible nature of the disease's progression, early diagnosis and interventional treatment has become particularly crucial. Considering the fact that serum and urine are the most commonly used specimens in clinical practice for detection, we conducted an analysis to identify the di ...[more]

PMID: 38164767

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