[HPP-2.0] The Comparable Microenvironment Shared by Colorectal Adenoma and Carcinoma: An Evidence of Stromal Proteomics

ABSTRACT: we initiated a proteomic project to survey stromal proteins responsive to adenoma and carcinoma of colorectal tissues. Most tissues of adjacent, adenoma, and carcinoma were individually sampled from CRC patients using LCM, after which tissue samples were subjected to proteomic analysis using high-resolution mass spectrometry and individual quantification in data-independent acquisition (DIA) mode. By integrating various datasets and bioinformatic algorithms, the analysis concluded that the epithelial proteomics were CRC stage-dependent, whereas the stromal proteomics in adenoma was comparable with that in carcinoma.

ORGANISM(S): Homo Sapiens

SUBMITTER: Jin Zi  

PROVIDER: PXD046176 | iProX | Tue Oct 17 00:00:00 GMT+01:00 2023

REPOSITORIES: iProX