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Reversible phosphorylation of a lectin receptor-like kinase controls xylem immunity

ABSTRACT: Pattern-recognition receptors (PRRs) mediate basal resistance to most phytopathogens. However, plant responses can be cell type-specific and the mechanisms governing xylem immunity remain largely unknown. We show that the lectin receptor-like kinase LORE contributes to xylem basal resistance in Arabidopsis upon infection with Ralstonia solanacearum, a destructive plant pathogen that colonizes the xylem to cause bacterial wilt. Following R. solanacearum infection, LORE is activated by phosphorylation at residue S761, initiating a phosphorelay that activates reactive oxygen species production and cell wall lignification. To prevent prolonged activation of immune signaling, LORE recruits and phosphorylates type 2C protein phosphatase LOPP, which dephosphorylates LORE and attenuates LORE-mediated xylem immunity to maintain immune homeostasis. A LOPP knockout confers resistance against bacterial wilt disease in Arabidopsis and tomatoes without impacting plant growth. Thus, our study reveals a regulatory mechanism in xylem immunity involving the reversible phosphorylation of receptor-like kinases

ORGANISM(S): Arabidopsis Thaliana

SUBMITTER: Yan Liang

PROVIDER: PXD046300 | iProX | Mon Oct 23 00:00:00 BST 2023

REPOSITORIES: iProX

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