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Distinct peptide profiles in human dura of CSDH

ABSTRACT: Whether dura mater derived endogenous peptides participate in the pathogenesis of CSDH remains undetermined. In the current study, the peptidomic profiles were performed in human dura of CSDH (three patients) and the relative control group (three non-CSDH samples) by LC-MS (liquid chromatography–mass spectrometry)

ORGANISM(S): Homo Sapiens

SUBMITTER: Xiaohua Dong

PROVIDER: PXD046368 | iProX | Wed Oct 25 00:00:00 BST 2023

REPOSITORIES: iProX

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Peptidomics insights: neutrophil extracellular traps (NETs) related to the chronic subdural hemorrhage.

Li Jie J Zhao Jing J Sun Shuchen S Shen Sen S Zhong Bincheng B Dong Xiaohua X

PeerJ 20231221

Chronic subdural hemorrhage (CSDH) refers to a hematoma with an envelope between the dura mater and the arachnoid membrane and is more common among the elderly. It was reported that the dura mater, which is highly vascularized with capillary beds, precapillary arterioles and postcapillary venules play an important role in the protection of the central nervous system (CNS). Numerous evidences suggests that peptides play an important role in neuroprotection of CNS. However, whether dura mater deri ...[more]

PMID: 38144176

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