The phosphorylation sites in GLI1 analyzed by mass-spec methodology
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Ximei Wu
PROVIDER: PXD046374 | iProX | Wed Oct 25 00:00:00 BST 2023
REPOSITORIES: iProX
Publications
Phosphorylation of human glioma-associated oncogene 1 on Ser937 regulates Sonic Hedgehog signaling in medulloblastoma.
Zeng Ling-Hui LH Tang Chao C Yao Minli M He Qiangqiang Q Qv Meiyu M Ren Qianlei Q Xu Yana Y Shen Tingyu T Gu Weizhong W Xu Chengyun C Zou Chaochun C Ji Xing X Wu Ximei X Wang Jirong J
Nature communications 20240202 1
Aberrant activation of sonic hedgehog (SHH) signaling and its effector transcriptional factor GLI1 are essential for oncogenesis of SHH-dependent medulloblastoma (MB<sub>SHH</sub>) and basal cell carcinoma (BCC). Here, we show that SHH inactivates p38α (MAPK14) in a smoothened-dependent manner, conversely, p38α directly phosphorylates GLI1 on Ser937/Ser941 (human/mouse) to induce GLI1's proteasomal degradation and negates the transcription of SHH signaling. As a result, Gli1<sup>S941E</sup> loss ...[more]
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