Effect of soluble egg antigen (SEA) from S. japonicum on gene expression in hepatic progenitor cells (HPC) cell line LE/6 and WB-F344
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ABSTRACT: Schistosomiasis is a serious but neglected tropical disease, which can cause granulomatous lesions and hepatic fibrosis. The egg-induced liver fibrosis is the primary cause of mortality and morbidity associated with this chronic disease. HPCs are a kind of stem cells with potentially bidirectional differentiation ability and interact with hepatic stellate cells during liver injury. We here reported the activation of HPCs during S. japonicum-induced liver fibrosis. SEA was used to stimulate HPC cell line LE/6 and WB-F344, and the differentiated gene expressions were shown to display the effect. Taken together, our data provides a moelcular framwork for SEA stimulation on HPCs during S. japonicum infection.
ORGANISM(S): Rattus Norvegicus
SUBMITTER:
Qian Chen
PROVIDER: PXD046558 | iProX | Wed Nov 01 00:00:00 GMT 2023
REPOSITORIES: iProX
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