Transcriptomic signatures of progressive and regressive liver fibrosis and portal hypertension

ABSTRACT: Persistent liver injury triggers a fibrogenic program that causes pathologic remodelling of the hepatic microenvironment (i.e., liver fibrosis) and portal hypertension. The dynamics of gene regulation during liver disease progression and regression remain understudied. Here, we generated hepatic transcriptome profiles in two well-established liver disease models at peak fibrosis and during spontaneous regression after the removal of the inducing agents. We linked the dynamics of key liver disease readouts, such as portal pressure, collagen proportionate area, and transaminase serum levels, to most differentially expressed genes, enabling the identification of transcriptomic signatures of progressive vs. regressive liver fibrosis and portal hypertension. These candidate biomarkers (e.g., Sc

INSTRUMENT(S): n/a, Illumina HiSeq 4000, CeMM HPC

ORGANISM(S): Mus musculus

SUBMITTER: Oleksandr Petrenko 

PROVIDER: E-MTAB-13804 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress