Mouse liver macrophage gene expression following hepatic fibrosis
Ontology highlight
ABSTRACT:
Macrophages were isolated from mouse livers 24 hours (inflammation) and 72 hours (resolution) following injury (hepatic fibrosis).
RNAs were prepared and hybrised on Affymetrix Mouse Genome 1.0 ST arrays.
ORGANISM(S): Mus musculus
SUBMITTER: Donald Dunbar
PROVIDER: E-MEXP-3177 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis.
Ramachandran Prakash P Pellicoro Antonella A Vernon Madeleine A MA Boulter Luke L Aucott Rebecca L RL Ali Aysha A Hartland Stephen N SN Snowdon Victoria K VK Cappon Andrea A Gordon-Walker Timothy T TT Williams Mike J MJ Dunbar Donald R DR Manning Jonathan R JR van Rooijen Nico N Fallowfield Jonathan A JA Forbes Stuart J SJ Iredale John P JP
Proceedings of the National Academy of Sciences of the United States of America 20121024 46
Although macrophages are widely recognized to have a profibrotic role in inflammation, we have used a highly tractable CCl(4)-induced model of reversible hepatic fibrosis to identify and characterize the macrophage phenotype responsible for tissue remodeling: the hitherto elusive restorative macrophage. This CD11B(hi) F4/80(int) Ly-6C(lo) macrophage subset was most abundant in livers during maximal fibrosis resolution and represented the principle matrix metalloproteinase (MMP) -expressing subse ...[more]
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This is a sub-model of a three-step
inflammatory response modelling study. The model includes distinct
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apoptotic neutrophil populations. Neutrophil apoptosis rate is
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This model is described in the article:
The resolution of
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Dunster JL, Byrne HM, King JR.
Bull. Math. Biol. 2014 Aug; 76(8):
1953-1980
Abstract:
There is growing interest in inflammation due to its
involvement in many diverse medical conditions, including
Alzheimer's disease, cancer, arthritis and asthma. The
traditional view that resolution of inflammation is a passive
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