USP18-mediated NCOA4 deISGylation and ferroptosis inhibition drives targeted therapy resistance in hepatocellular carcinoma
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ABSTRACT: To elucidate the principal downstream mediator responsible for USP18-mediated Sorafenib resistance in HCC, we conducted cluster analysis on the differential protein expression based on the whole-proteome analysis of HepG2 cells with or without overexpression of USP18 (HepG2-USP18-OE vs. HepG2-Ctrl), we identified 47 commonly downregulated proteins and 31 upregulated proteins .
ORGANISM(S): Homo Sapiens
SUBMITTER: Hao Zhang
PROVIDER: PXD047888 | iProX | Sun Dec 17 00:00:00 GMT 2023
REPOSITORIES: iProX
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