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Shigella induces stress granule formation by ADP-riboxanation of the eIF3 complex

ABSTRACT: We utilized a large-scale proteomic profiling strategy to quantitatively measure ADP-riboxanation (and classical ADP-ribosylation) levels of host proteins upon introduction of bacterial effectors. Notably, we identified the eukaryotic translation initiation factor 3 (eIF3) complex as a novel target of the OspC family proteins. ADP-riboxanation of eIF3 resulted in inhibition of bulk protein synthesis and SG assembly in infected host cells, which promoted intracellular bacterial proliferation.

ORGANISM(S): Homo Sapiens

SUBMITTER: Xiaoyun Liu

PROVIDER: PXD048666 | iProX | Thu Jan 18 00:00:00 GMT 2024

REPOSITORIES: iProX

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