IRF3 and HIF hydroxylation by EGLN1
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Wuhan Xiao
PROVIDER: PXD048667 | iProX | Thu Mar 21 00:00:00 GMT 2024
REPOSITORIES: iProX
Publications
Oxygen enhances antiviral innate immunity through maintenance of EGLN1-catalyzed proline hydroxylation of IRF3.
Liu Xing X Tang Jinhua J Wang Zixuan Z Zhu Chunchun C Deng Hongyan H Sun Xueyi X Yu Guangqing G Rong Fangjing F Chen Xiaoyun X Liao Qian Q Jia Shuke S Liu Wen W Zha Huangyuan H Fan Sijia S Cai Xiaolian X Gui Jian-Fang JF Xiao Wuhan W
Nature communications 20240426 1
Oxygen is essential for aerobic organisms, but little is known about its role in antiviral immunity. Here, we report that during responses to viral infection, hypoxic conditions repress antiviral-responsive genes independently of HIF signaling. EGLN1 is identified as a key mediator of the oxygen enhancement of antiviral innate immune responses. Under sufficient oxygen conditions, EGLN1 retains its prolyl hydroxylase activity to catalyze the hydroxylation of IRF3 at proline 10. This modification ...[more]
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