Proteome of Pseudomonas aeruginosa treated by non-antibiotic pharmaceutical
Ontology highlight
ABSTRACT:
ORGANISM(S): Pseudomonas Aeruginosa Pao1
SUBMITTER: 
Kaihu Yao
PROVIDER: PXD048908 | iProX | Fri Jan 26 00:00:00 GMT 2024
REPOSITORIES: iProX
Publications
Non-antibiotic pharmaceutical phenylbutazone binding to MexR reduces the antibiotic susceptibility of Pseudomonas aeruginosa.
Dong Limin L Sun Lang L Yang Yan Y Yuan Lin L Gao Wei W Yu Dan D Meng Qinghong Q Shi Wei W Wang Qing Q Li Yue Y Zhang Youwen Y You Xuefu X Yao Kaihu K
Microbiological research 20240811
Antimicrobial resistance has been an increasingly serious threat to global public health. The contribution of non-antibiotic pharmaceuticals to the development of antibiotic resistance has been overlooked. Our study found that the anti-inflammatory drug phenylbutazone could protect P. aeruginosa against antibiotic mediated killing by binding to the efflux pump regulator MexR. In this study, antibiotic activity against P. aeruginosa alone or in combination with phenylbutazone was evaluated in vit ...[more]
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