Ontology highlight
ABSTRACT:
ORGANISM(S): Serratia Marcescens Lct-sm213
SUBMITTER: Xiaoyun Liu
PROVIDER: PXD050178 | iProX | Tue Feb 27 00:00:00 GMT 2024
REPOSITORIES: iProX
Nature microbiology 20240422
The cyclic-oligonucleotide-based anti-phage signalling system (CBASS) is a type of innate prokaryotic immune system. Composed of a cyclic GMP-AMP synthase (cGAS) and CBASS-associated proteins, CBASS uses cyclic oligonucleotides to activate antiviral immunity. One major class of CBASS contains a homologue of eukaryotic ubiquitin-conjugating enzymes, which is either an E1-E2 fusion or a single E2. However, the functions of single E2s in CBASS remain elusive. Here, using biochemical, genetic, cryo- ...[more]