The molecular mechanisms of imatinb treatment on acute lung injury in septic mice through proteomic technology

ABSTRACT: A septicemia model was established by intraperitoneal injection of lipopolysaccharide (LPS), followed by tail vein injection of imatinib in the treatment group and normal saline injection in the control group. Flow cytometry was used to detect inflammatory factors, and hematoxylin staining was used to detect pathological injury to the lung tissue. TMT quantitative labeling technology was used for proteomic sequencing analysis. The main target protein was identified through bioinformatics and its expression was confirmed using western blotting.

ORGANISM(S): Mus Musculus

SUBMITTER: Zhenyu Li  

PROVIDER: PXD050204 | iProX | Tue Feb 27 00:00:00 GMT 2024

REPOSITORIES: iProX