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The molecular mechanisms of imatinb treatment on acute lung injury in septic mice through proteomic technology

ABSTRACT: A septicemia model was established by intraperitoneal injection of lipopolysaccharide (LPS), followed by tail vein injection of imatinib in the treatment group and normal saline injection in the control group. Flow cytometry was used to detect inflammatory factors, and hematoxylin staining was used to detect pathological injury to the lung tissue. TMT quantitative labeling technology was used for proteomic sequencing analysis. The main target protein was identified through bioinformatics and its expression was confirmed using western blotting.

ORGANISM(S): Mus Musculus

SUBMITTER: Zhenyu Li

PROVIDER: PXD050204 | iProX | Tue Feb 27 00:00:00 GMT 2024

REPOSITORIES: iProX

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The Molecular Mechanisms of Imatinib Treatment on Acute Lung Injury in Septic Mice Through Proteomic Technology.

Wang Xiao X Zhou ZhiQing Z Li DuanYang D Zhang BoYang B Zong XiaoLong X Liang Xue X Li ZhenYu Z

Journal of immunology research 20250609

<b>Background:</b> Acute lung injury (ALI) is the most common complication of sepsis. Despite considerable progress in the treatment of sepsis, the effective treatment strategies are lacking. A previous study has shown that imatinib reduces the rate of acute pulmonary damage in septic mice; however, the molecular mechanism remains unclear. Therefore, the current study aimed to investigate the potential mechanism by which imatinib alleviates ALI in septic mice. <b>Methods:</b> A septicemia model ...[more]

PMID: 40524944

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