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Substrate and Functional Characterization of the Lysine Acetyltransferase and Deacetylase in Mycobacteria

ABSTRACT: We utilized the non-pathogenic M. smegmatis strain as a model and systematically investigated the dynamic proteome changes in response to the overexpressing of MsKat/MtCobB in mycobacteria. After that, the quantitative mass spectrometric method was utilized and showed that the AMP-dependent synthetase, Citrate synthase, ATP-dependent specificity component of the Clp protease, and ATP-dependent DNA/RNA helicases were identified to be the substrates of MsKat.

ORGANISM(S): Mycolicibacterium Smegmatis Mc2 51

SUBMITTER: Minjia Tan

PROVIDER: PXD050791 | iProX | Wed Mar 20 00:00:00 GMT 2024

REPOSITORIES: iProX

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