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Comprehensive Proteomic Characterization of Scar Formation in Urethral Stricture Disease

ABSTRACT: Male urethral stricture disease (USD) is characterized by scar formation, whose molecular mechanism is still lack. In this study, we performed comprehensive proteomic landscape of USD with 12 scar tissues and 5 matched normal adjacent tissues (NATs). Comparative analysis disclosed the ECM signaling and complement cascade were overrepresented in the scar tissues, in which COL11A1, CNN2, and CD248 would play positive impacts.

ORGANISM(S): Homo Sapiens

SUBMITTER: Chen Ding

PROVIDER: PXD053186 | iProX | Tue Jun 18 00:00:00 BST 2024

REPOSITORIES: iProX

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Comprehensive proteomic characterization of urethral stricture disease in the Chinese population.

Gao Jiangtao J Liu Hui H Li Lingling L Guo Chunmei C Wang Zhiyong Z Cheng Mengya M Tan Subei S Chen Lu L Shi Jijing J Wu Hui H Feng Chao C Yu Guoying G Ding Chen C

Frontiers in molecular biosciences 20240726

<h4>Background</h4>Male urethral stricture disease (USD) is predominantly characterized by scar formation. There are few effective therapeutic drugs, and comprehensive molecular characterizations of USD formation remain undefined.<h4>Methods</h4>The proteomic profiling of twelve scar tissues and five matched normal adjacent tissues (NATs). Proteomic analysis methods were applied to explore the molecular characterizations of USD formation, including uncovering mechanistic pathways and providing n ...[more]

PMID: 39130371

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