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Proteomic analysis of bone marrow-derived macrophages after Nano-IFNγ/Zole and GGPP incubation

ABSTRACT: We designed and prepared a bisphosphonate-mineralized Nano-IFNγ (Nano-IFNγ/Zole) to promote trans-differentiation of macrophages from the M2 to M1 type. Bisphosphonate in the Nano-IFNγ/Zole reduced lysosomal acidification by inhibiting isoprene modification of Rab family proteins, enhanced tumor antigen cross-presentation and activated the TFEB pathway. These mechanisms, in conjunction with IFNγ-activated JAK/STAT1 signaling, facilitated the trans-differentiation of macrophages.

ORGANISM(S): Mus Musculus

SUBMITTER: Qiang Zhang

PROVIDER: PXD053688 | iProX | Fri Jul 05 00:00:00 BST 2024

REPOSITORIES: iProX

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Bisphosphonate-mineralized nano-IFNγ suppresses residual tumor growth caused by incomplete radiofrequency ablation through metabolically remodeling tumor-associated macrophages.

Yan Zhicheng Z Wang Bing B Shen Yuhan Y Ren Junji J Chen Meifang M Jiang Yunhui Y Wu Hao H Dai Wenbing W Zhang Hua H Wang Xueqing X Zhang Qiang Q Yang Wei W He Bing B

Theranostics 20250101 3

<b>Rationale:</b> Radiofrequency ablation (RFA), as a minimally invasive surgery strategy based on local thermal-killing effect, is widely used in the clinical treatment of multiple solid tumors. Nevertheless, RFA cannot achieve the complete elimination of tumor lesions with larger burden or proximity to blood vessels. Incomplete RFA (iRFA) has even been validated to promote residual tumor growth due to the suppressive tumor immune microenvironment (TIME). Therefore, exploring strategies to remo ...[more]

PMID: 39776793

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