Proteomic analysis of bone marrow-derived macrophages after Nano-IFNγ/Zole and GGPP incubation

ABSTRACT: We designed and prepared a bisphosphonate-mineralized Nano-IFNγ (Nano-IFNγ/Zole) to promote trans-differentiation of macrophages from the M2 to M1 type. Bisphosphonate in the Nano-IFNγ/Zole reduced lysosomal acidification by inhibiting isoprene modification of Rab family proteins, enhanced tumor antigen cross-presentation and activated the TFEB pathway. These mechanisms, in conjunction with IFNγ-activated JAK/STAT1 signaling, facilitated the trans-differentiation of macrophages.

ORGANISM(S): Mus Musculus

SUBMITTER: Qiang Zhang  

PROVIDER: PXD053688 | iProX | Fri Jul 05 00:00:00 BST 2024

REPOSITORIES: iProX