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Murine osteoblast, supernatant and serum mass spectrometry analysis

ABSTRACT: Mass spec data of murine osteoblast, serum and supernatant

ORGANISM(S): Mus Musculus

SUBMITTER: Ren Xu

PROVIDER: PXD054258 | iProX | Thu Jul 25 00:00:00 BST 2024

REPOSITORIES: iProX

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Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion.

Li Zan Z Shi Baohong B Li Na N Sun Jun J Zeng Xiangchen X Huang Rui R Bok Seoyeon S Chen Xiaohui X Han Jie J Yallowitz Alisha R AR Debnath Shawon S Cung Michelle M Ling Zheng Z Zhong Chuan-Qi CQ Hong Yixang Y Li Gang G Koenen Mascha M Cohen Paul P Su Xinhui X Lu Hongbin H Greenblatt Matthew B MB Xu Ren R

Nature communications 20240806 1

The skeleton has been suggested to function as an endocrine organ controlling whole organism energy balance, however the mediators of this effect and their molecular links remain unclear. Here, utilizing Schnurri-3-/- (Shn3-/-) mice with augmented osteoblast activity, we show Shn3-/-mice display resistance against diet-induced obesity and enhanced white adipose tissue (WAT) browning. Conditional deletion of Shn3 in osteoblasts but not adipocytes recapitulates lea ...[more]

PMID: 39107299

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