Dataset Information
Ren Xu 
Publications
Bone controls browning of white adipose tissue and protects from diet-induced obesity through Schnurri-3-regulated SLIT2 secretion.
Nature communications 20240806 1
The skeleton has been suggested to function as an endocrine organ controlling whole organism energy balance, however the mediators of this effect and their molecular links remain unclear. Here, utilizing Schnurri-3<sup>-/-</sup> (Shn3<sup>-/-</sup>) mice with augmented osteoblast activity, we show Shn3<sup>-/-</sup>mice display resistance against diet-induced obesity and enhanced white adipose tissue (WAT) browning. Conditional deletion of Shn3 in osteoblasts but not adipocytes recapitulates lea ...[more]
