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Proteomic analysis of the effects of Shenzhu Tiaopi granules on model rats with type 2 diabetes mellitus

ABSTRACT: In total, 5856 proteins were identified via proteomics analysis, 97 of which were significantly differentially expressed in the liver and affected fatty acid metabolism, unsaturated fatty acid biosynthesis, the peroxisome proliferator-activated receptor (PPAR) signalling pathway, pyruvate metabolism, and terpenoid backbone biosynthesis. Screening identified 10 target proteins, including perilipin‐2 (Plin2), Pdk4, farnesyl diphosphate synthase (Fdps) and Fdft1. Among these, the key proteins were Plin2 and Fdps, which were found to be associated with the PPAR signalling pathway and terpenoid backbone biosynthesis via the relationship networks

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Jindong Zhao

PROVIDER: PXD055444 | iProX | Fri Aug 30 00:00:00 BST 2024

REPOSITORIES: iProX

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