VCP enhances autophagy-related osteosarcoma progression by recruiting USP2 to inhibit ubiquitination and degradation of FASN
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Zhili Liu
PROVIDER: PXD055763 | iProX | Tue Sep 10 00:00:00 BST 2024
REPOSITORIES: iProX
Publications
VCP enhances autophagy-related osteosarcoma progression by recruiting USP2 to inhibit ubiquitination and degradation of FASN.
Wang Shijiang S Nie Jiangbo J Jiang Haoxin H Li Anan A Zhong Nanshan N Tong Weilai W Yao Geliang G Jiang Alan A Xie Xinsheng X Zhong Yanxin Y Shu Zhiguo Z Liu Jiaming J Yang Feng F Liu Zhili Z
Cell death & disease 20241103 11
Osteosarcoma (OS) is a highly aggressive malignant tumor with a high rate of disability and mortality rates, and dysregulated autophagy is a crucial factor in cancer. However, the molecular mechanisms that regulate autophagy in OS remain unclear. This study aimed to explore key molecules that affect autophagy in OS and their regulatory mechanisms. We found that fatty acid synthase (FASN) was significantly increased in activated autophagy models of OS and promoted OS proliferation in an autophagy ...[more]
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