Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Proteomic Insights into the Regulatory Role of CobQ Deacetylase in Aeromonas hydrophila

ABSTRACT: This study utilizes quantitative proteomics to investigate the impact of the cobQ deletion (ΔahcobQ) on the global protein expression profile in A. hydrophila.

ORGANISM(S): Aeromonas Hydrophila

SUBMITTER: Xiangmin Lin

PROVIDER: PXD056207 | iProX | Tue Sep 24 00:00:00 BST 2024

REPOSITORIES: iProX

ACCESS DATA

Json Xml

Publications

Proteomic Insights into the Regulatory Role of CobQ Deacetylase in Aeromonas hydrophila.

Wang Guibin G Chen Linxin L Lian Juanqi J Gong Lanqing L Tian Feng F Wang Yuqian Y Lin Xiangmin X Liu Yanling Y

Journal of proteome research 20241211 1

Post-translational modifications are crucial in regulating biological functions across both prokaryotes and eukaryotes. In Aeromonas hydrophila, CobQ, a recently identified novel deacetylase, plays a significant role in lysine deacetylation, influencing bacterial metabolism and stress responses. The present study utilized quantitative proteomics to investigate the impact of cobQ deletion on the global protein expression profile in A. hydrophila. Through data-independent acqu ...[more]

PMID: 39659247

Similar Datasets

Aeromonas hydrophila whole cell differential proteins

Project description:Differential protein of Aeromonas hydrophila(putative human infections)'s whole cell protein

2022-01-13 | PXD029702 | Pride

Time-resolved and multi-tissue RNAseq provided new insights on the immune responses of European eels following infection with Aeromonas hydrophila

Project description:No studies systematically compared time-resolved and multi-tissue innate immune responses for European eels (Anguilla anguilla) with Aeromonas hydrophila infection through a high throughput method. Here, we challenged European eels with A. hydrophila (infected) or PBS (control). A low fatality rate (16.1%) was observed for infected group at 2 days post-infection (dpi). Then we examined transcriptional profiles of intestines, livers and spleens from 12 European eels with/without the infection of A. hydrophila at 6, 18 and 36 hours post-infection (hpi). The results showed that the most differentially expressed genes (DEGs) were found in the spleens at 6 hpi (7569 DEGs), followed by the intestines at 6 hpi (3129 DEGs) and the livers at 18 hpi (2722 DEGs). Only a few DEGs were found in three tissues at 36 hpi. The comparisons for DEGs numbers and KEGG enrichments suggested a consistent time-course immune responses among these three tissues. A similar enrichment of PRRs-related pathways including TLRs, NLRs and RLRs was revealed in the livers and spleens, but not in the intestines. Among immune-related DEGs, 62 paralogues pairs were found, and the expression trends of most paralogues pairs were consistent. Some paralogues of immune-related DEGs had unique domains. Furthermore, a larger clusters representing the similar tissue were revealed for the intestines and spleens. The distinct cytokine signal transduction and interaction existed between the livers and spleens. Altogether, the present study provides time-resolved and multi-tissue transcriptome characteristics of A. anguilla in response to A. hydrophila infection.

2024-11-01 | GSE188550 | GEO

Aeromonas hydrophila subsp. hydrophila

Project description:Aeromonas hydrophila subsp. hydrophila Genome sequencing

| PRJNA438389 | ENA

Aeromonas hydrophila

Project description:Aeromonas hydrophila genome

| PRJDB10903 | ENA

Antibiotic resistance in Aeromonas hydrophila associated with exposure to low levels of oxytetracycline

Project description:Antibiotic resistance (AMR) in aquatic bacteria affecting aquaculture has been a growing concern given the potential for mixing of bacterial populations in the aquatic environment and exposure to different pharmaceuticals from drugs used in aquaculture, as well as wastewater effluent and agricultural run-off. To better understand the mechanism for AMR in a common aquatic fish pathogen exposed to low dose antibiotics we monitored the genetic changes, as well as gene expression, in Aeromonas hydrophila as the bacteria was exposed to incremental doses of oxytetracycline (OTC), a commonly used drug in aquaculture. We were able to render all three isolates of our original A. hydrophila resistant to therapeutic levels of OTC (i.e. ≥100ppm). The relatively quick phenotypic adaptation (often less than 3 days) to different OTC concentrations was very similar across our replicates. Our whole genome sequencing data and transcriptome results suggested several genes underwent point mutations across all replicates. Further differential gene expression was observed and likely impacted several pathways which may explain the progressive resistance to OTC associated with incremental exposure to the drug. The specific mutations consistently identified in isolates exposed to OTC were on AHA_ 2785 (associated with an outer membrane protein), AHA_2910 (involved in the efflux pump mechanism), and AHA_0308 (associated with the small ribosomal subunit protein S10). The pathways involved in the differential gene expression included efflux- pump mechanisms, outer membrane proteins, and ribosomal protein OTC target. Our findings support the notion that AMR can occur via genetic regulation of several intrinsic mechanisms within a bacterial population. This finding could have implications in aquaculture where bacteria such as A. hydrophila can be exposed to varying levels of antibiotics during in-feed treatments.

2025-10-01 | GSE290492 | GEO

Aeromonas hydrophila

Project description:Aeromonas hydrophila Genome sequencing

| PRJNA1031986 | ENA

Aeromonas hydrophila

Project description:Aeromonas hydrophila Genome sequencing

| PRJNA590943 | ENA

Aeromonas hydrophila

Project description:Aeromonas hydrophila Genome sequencing

| PRJNA908208 | ENA

Aeromonas hydrophila

Project description:Aeromonas hydrophila Genome sequencing