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Identification and sequencing of CD36 interacting proteins in cardiomyocytes

ABSTRACT: Identification and sequencing of CD36 interacting proteins in cardiomyocytes

ORGANISM(S): Mus Musculus

SUBMITTER: Jiamin Li

PROVIDER: PXD056711 | iProX | Fri Oct 11 00:00:00 BST 2024

REPOSITORIES: iProX

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Inhibiting CD36 palmitoylation improves cardiac function post-infarction by regulating lipid metabolic homeostasis and autophagy.

Zhang Qingwei Q Li Jiamin J Liu Xin X Chen Ximing X Zhu Liwei L Zhang Zhen Z Hu Yingying Y Zhao Tong T Lou Han H Xu Henghui H Zhao Wenjie W Dong Xinxin X Sun Zeqi Z Sun Xiuxiu X Yang Baofeng B Zhang Yong Y

Nature communications 20250717 1

Alterations in myocardial energy substrate metabolism and mitochondrial injury following myocardial infarction (MI) lead to structural and functional abnormalities of the heart. The fatty acid translocase CD36 (CD36) plays a pivotal role in regulating lipid homeostasis and mitochondrial metabolism. Here, we demonstrate that inhibiting the palmitoylation of CD36 and the resulting alteration in its subcellular localization alleviates lipid metabolism disorders and mitochondrial dysfunction in card ...[more]

PMID: 40675975

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