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Repurposing Etalocib suppresses multidrug-resistant staphylococcus aureus

ABSTRACT: Staphylococcus aureus (S. aureus) is common gram-positive bacteria that prominently causes community acquired infection (CAI) and hospital acquired infection (HAI) makes it a versatile and dangerous, Antibiotic resistance and the long - term nature of new drug research and development have forced the search for new research methods of antibacterial drugs. Drug repositioning is a new research approach for antibacterial drugs. Etalocib is found through screening the compound library, and its antibacterial activity is studied and the antibacterial mechanism is explored.

ORGANISM(S): Staphylococcus Aureus

SUBMITTER: Zewen Wen

PROVIDER: PXD057734 | iProX | Mon Nov 11 00:00:00 GMT 2024

REPOSITORIES: iProX

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Repurposing Etalocib suppresses multidrug-resistant Staphylococcus aureus by disrupting the bacterial membrane.

Huang Xuancheng X Li Congcong C Zhang Chaoqin C Xiang Yong Y Yu Zhijian Z Li Peiyu P Bai Bing B Wen Zewen Z Hou Tieying T

BMC microbiology 20250801 1

<h4>Background</h4>The emergence of multidrug-resistant (MDR) Staphylococcus aureus (S. aureus) seriously poses a serious threat to human health and presents a significant clinical challenge. Therefore, it is urgent to explore alternative treatments and develop novel antimicrobial agents. To investigate the antibacterial activity of Etalocib against S. aureus and elucidate its underlying mechanism of action.<h4>Results</h4>Etalocib, a drug previously investigated in clinical trials, exhibited no ...[more]

PMID: 40750851

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