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GSK2018682 against Staphylococcus aureus proteome

ABSTRACT: Staphylococcus aureus (S, aureus) is common gram-positive bacteria that prominently causes community acquired infection (CAl) and hospital acquired infection (HAl) makes it a versatile and dangerous, Antibiotic resistance and the long - term nature of new drug research and development have forced the search for new research methods of antibacterial drugs. Drug repositioning is a new research approach for antibacterial drugs. GSK2018682 is found through screening the compound library, and its antibacterial activity is studied and the antibacterial mechanism is explored.

ORGANISM(S): Staphylococcus Aureus

SUBMITTER: Zewen Wen

PROVIDER: PXD066899 | iProX | Fri Aug 01 00:00:00 BST 2025

REPOSITORIES: iProX

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Repurposing GSK2018682 Confers Dual Antibacterial and Antibiofilm Activity against Staphylococcus aureus.

Huang Xuancheng X Li Congcong C He Yunhui Y Liu Baolan B Yan Qin Q Yu Zhijian Z Chai Bao B Wen Zewen Z Fang Fang F Hou Tieying T

ACS infectious diseases 20260112 2

The increase in the level of antibiotic-resistant Staphylococcus aureus underscores the urgent need for novel therapeutics. Consequently, repurposing clinically approved drugs has emerged as a compelling and time-saving strategy to counteract this escalating antimicrobial crisis. Here, high-throughput screening revealed that GSK2018682, an agonist of sphingosine-1-phosphate receptors S1P1 and S1P5, exhibits potent, broad-spectrum antimicrobial activity, particularly against S. aureus</ ...[more]

PMID: 41525229

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