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Proteomics profile of large extracellular vesicles derived from P. gingivalis–infected HCT116 cells

ABSTRACT: HCT116 cells were treated with/without P. gingivalis for 48h, then the large extracellular vesicles (lEV) were isolated via a series of differential centrifugation steps. then the purified lEVs were used for label free quantitative proteomics analysis. Three biological replicates are prepared for each group.

ORGANISM(S): Homo Sapiens

SUBMITTER: Fuping Wen

PROVIDER: PXD059913 | iProX | Fri Jan 17 00:00:00 GMT 2025

REPOSITORIES: iProX

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Multiomics profiling reveals that <i>P. gingivalis</i>-induced extracellular vesicle reprogramming promotes immune evasion in colorectal cancer through autophagy-mediated STING degradation.

Zhang Xu X Huang Jieying J Shang Guangwei G Lu Yang Y Liu Haixia H Zhang Yiming Y Wen Fuping F Xu Yuanzhi Y

Frontiers in cellular and infection microbiology 20251015

<h4>Objective</h4><i>Porphyromonas gingivalis</i> (<i>P. gingivalis</i>) infection is a recognized pathogenic factor in colorectal cancer (CRC), and extracellular vesicles (EVs) are key mediators within the tumor microenvironment. However, the molecular composition of large extracellular vesicles (lEVs) derived from <i>P. gingivalis</i>-infected cancer cells remains poorly characterized. This study aimed to comprehensively define the molecular cargo alterations in lEVs secreted by CRC cells in r ...[more]

PMID: 41170290

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