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Proteomic Profiling of Pregnancy Day 8 Decidua in Uterine Localized Cadmium-Exposed Mice

ABSTRACT: This study investigates cadmium-induced proteomic alterations in gestational day 8 decidua using a uterine-localized exposure mouse model. Female ICR mice (7-8 weeks) received daily vaginal CdCl₂ (0.01 mg/mL, 100 μL) under isoflurane anesthesia (n=3 biological replicates). Tissues were snap-frozen in liquid nitrogen post-GD8 collection. Ultra Deep quantitative proteomics with diaPASEF acquisition (timsTOF Pro2, Wuhan Maiwei) revealed differential protein expression profiles associated with Cd exposure during early pregnancy.

ORGANISM(S): Mus Musculus

SUBMITTER: Xiaofeng Xu

PROVIDER: PXD062021 | iProX | Wed Mar 19 00:00:00 GMT 2025

REPOSITORIES: iProX

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