RSDR, a Novel Potential Biomarker, Protects Against AKI by Interacting with hnRNPK to Regulate DHODH-Mediated Ferroptosis
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Fan Cheng
PROVIDER: PXD062047 | iProX | Wed Mar 19 00:00:00 GMT 2025
REPOSITORIES: iProX
Publications
The long non-coding RNA RSDR protects against acute kidney injury in mice by interacting with hnRNPK to regulate DHODH-mediated ferroptosis.
Li Bojun B Lin Fangyou F Song Baofeng B Han ShangTing S Ye Zehua Z Sun Yushi Y Wang Peihan P Xia Yuqi Y Yu Weimin W Zhou Xiangjun X Cheng Fan F
Nature communications 20250812 1
Acute kidney injury (AKI) is a serious clinical condition whose underlying mechanisms remain unclear. Here we identify a long non-coding RNA, RSDR, as a critical regulator of renal protection in AKI. RSDR interacts with the RNA-binding protein hnRNPK, forming a positive feedback loop that enhances the transcription of DHODH, a key ferroptosis-suppressing gene. Mechanistically, RSDR promotes the nuclear retention of hnRNPK and facilitates epigenetic activation of DHODH, thereby limiting ferroptos ...[more]
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