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Mechanism of Zuogui Wan in ameliorating chronic stress-induced intergenerational transmission of ovarian dysfunction via the complement and coagulation cascade pathway

ABSTRACT: To systematically identify protein targets interacting with traditional Chinese medicine Zuogui Wan, limited proteolysis mass spectrometry (LiP-MS) was employed as a high-throughput screening platform. To investigate the molecular mechanisms underlying chronic unpredictable mild stress (CUMS)-induced Premature ovarian insufficiency (POI), we performed data-independent acquisition (DIA) quantitative proteomics on ovarian tissues from three generations of rats (Control vs. Model groups).

ORGANISM(S): Rattus Rattus

SUBMITTER: Min Zhao

PROVIDER: PXD063422 | iProX | Tue Apr 29 00:00:00 GMT+01:00 2025

REPOSITORIES: iProX

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