Dataset Information
Quantitative proteomic analysis of UUO-14d kidneys from Adamts18+/+ versus Adamts18−/− mice using label-free LC-MS/MS
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Wei Zhang
PROVIDER: PXD064042 | iProX | Mon May 19 00:00:00 GMT+01:00 2025
REPOSITORIES: iProX
Publications
The secreted protease ADAMTS18 is a novel activator of latent TGF-β to exacerbate renal fibrosis.
Communications biology 20250607 1
Renal fibrosis (RF) is an inevitable consequence of almost all forms of progressive chronic kidney disease (CKD). TGFβ is a powerful cytokine capable of dominating the fibrotic process. Targeting factors capable of activating latent TGF-β is a more effective and safe strategy to reduce TGF-β-induced fibrosis, but appropriate targets need to be identified. Here, we show that ADAMTS18/Adamts18 is significantly upregulated in the fibrotic kidneys of human CKD patients and mice. ADAMTS18 is primaril ...[more]
