DDX39B K63-linked ubiquitination mediated by TRIM28 promotes NSCLC metastasis by enhancing ECAD lysosomal degradation

ABSTRACT: DDX39B interacted with E3 ubiquitin ligase TRIM28 and underwent TRIM28-mediated K63-linked ubiquitination at Lys241, Lys384, and Lys398, leading to DDX39B protein stabilization and upregulation.

ORGANISM(S): Homo Sapiens

SUBMITTER: Ping Lin  

PROVIDER: PXD064812 | iProX | Tue Jun 10 00:00:00 BST 2025

REPOSITORIES: iProX