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Proteomic Analysis of Human Nucleus Pulposus in Young and Elderly Individuals Using TMT Quantification

ABSTRACT: This project investigates the differential proteomic profiles of human nucleus pulposus samples from young and elderly individuals. Using Tandem Mass Tag (TMT) quantification, we aim to identify and compare protein expression differences between the two groups. The research explores the biological implications of these differences, with a focus on understanding age-related changes at the molecular level in the nucleus pulposus, a key component of the intervertebral disc.

ORGANISM(S): Homo Sapiens

SUBMITTER: Wei Wang

PROVIDER: PXD065307 | iProX | Mon Jun 23 00:00:00 BST 2025

REPOSITORIES: iProX

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CXCL14 drives age-related intervertebral disc degeneration via NF-κB pathway activation in a multiomic study.

Zhou Tianle T Zhang Tonghui T He Qiwang Q Zhang Zhiwen Z Huang Yong Y Chen Zijun Z Wang Wei W

Scientific reports 20250713 1

Intervertebral disc degeneration (IDD), a common cause of chronic low back pain, strongly impacts daily life. Although previous studies have identified certain biomarkers indicating IDD, comprehensive analyses that integrate transcriptomic and proteomic data to elucidate age-related changes in IDD are lacking. We addressed this issue by integrating transcriptomic and proteomic analyses to identify key molecular signatures that may be potential therapeutic targets for improving the treatment of a ...[more]

PMID: 40653514

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