Proteomic analysis of periodontal tissue reveals β-guanidinopropionic acid (β-GPA) mediated inhibition of the TLR4 pathway in a mouse model of hyperlipidemic periodontitis.

ABSTRACT: This project aims to elucidate the molecular mechanisms by which the gut microbial metabolite β-guanidinopropionic acid (β-GPA) alleviates hyperlipidemic periodontitis (HPD). We performed Tandem Mass Tag (TMT) based quantitative proteomic analysis on periodontal tissues from HPD model mice versus those treated with β-GPA. The goal was to identify key differentially expressed proteins and uncover the protective signaling pathways modulated by β-GPA, ultimately identifying the TLR4-MyD88 axis as a primary therapeutic target.

ORGANISM(S): Mus Musculus

SUBMITTER: Min Hu  

PROVIDER: PXD069376 | iProX | Mon Oct 13 00:00:00 BST 2025

REPOSITORIES: iProX