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Quantitative proteomic analysis reveals the inflammatory regulation and immune activation of mild magnetic hyperthermia in bladder cancer

ABSTRACT: Inflammatory responses and immune regulation in bladder cancer treatment are critical to therapeutic efficacy, yet their specific mechanisms and protein-level changes remain unclear. Previous studies have shown that an immunosuppressive tumor microenvironment and excessive neutrophil infiltration lead to poor therapeutic safety and efficacy. In this study, a mild magnetic hyperthermia (mMHT) protocol was employed to perform low-temperature tumor magnetic hyperthermia, successfully achieving tumor inhibition and inflammation modulation in a bladder cancer-bearing mouse model. Through proteomic analysis of tumor tissues from treated mice, the mechanisms of mMHT against bladder cancer were elucidated, particularly its roles in immune activation and inflammation suppression. mMHT induces significant global protein expression reprogramming, and principal component analysis (PCA) revealed clear distinctions among the five groups, indicating distinct proteomic profiles. Differential protein analysis showed that, compared with the control group (MB49a), the mMHT group (MB49e) exhibited 2,391 upregulated proteins and 3,133 downregulated proteins, with the most pronounced differences observed relative to the three single-treatment groups. Venn analysis identified 3,259 unique differential proteins in the mMHT group, highlighting the synergistic molecular response network triggered by the combination of magnetic hyperthermia and NO therapy.

ORGANISM(S): Mus Musculus

SUBMITTER: Jiawei Liu

PROVIDER: PXD070387 | iProX | Wed Nov 05 00:00:00 GMT 2025

REPOSITORIES: iProX

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Project description:The paper describes a model on the Dynamics of Immune Checkpoints, Immune System, and BCG in the Treatment of Superficial Bladder Cancer. Created by COPASI 4.25 (Build 207) This model is described in the article: Dynamics of Immune Checkpoints, Immune System, and BCG in the Treatment of Superficial Bladder Cancer Farouk Tijjani Saad, Evren Hincal, and Bilgen Kaymakamzade Computational and Mathematical Methods in Medicine, vol. 2017, no. 3573082 Abstract: This paper aims to study the dynamics of immune suppressors/checkpoints, immune system, and BCG in the treatment of superficial bladder cancer. Programmed cell death protein-1 (PD-1), cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), and transforming growth factor-beta (TGF-b) are some of the examples of immune suppressors/checkpoints. They are responsible for deactivating the immune system and enhancing immunological tolerance. Moreover, they categorically downregulate and suppress the immune system by preventing and blocking the activation of T-cells, which in turn decreases autoimmunity and enhances self- tolerance. In cancer immunotherapy, the immune checkpoints/suppressors prevent and block the immune cells from attacking, spreading, and killing the cancer cells, which leads to cancer growth and development. We formulate a mathematical model that studies three possible dynamics of the treatment and establish the effects of the immune checkpoints on the immune system and the treatment at large. Although the effect cannot be seen explicitly in the analysis of the model, we show it by numerical simulations. This model is hosted on BioModels Database and identified by: MODEL1907100001. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

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Quantitative proteomic analysis reveals the inflammatory regulation and immune activation of mild magnetic hyperthermia in bladder cancer

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