Proteomics

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Andrographolide attenuates microglial senescence in a 5×FAD mouse model of Alzheimer's disease by suppressing the STAT3 signaling pathway


ABSTRACT: Andrographolide (AP), a diterpenoid compound extracted from Andrographis paniculata, has been shown to be a promising therapy for Alzheimer's disease (AD) in preclinical studies, but the involved mechanisms still need to be clarified. Here we showed that AP improved cognition function and reduced amyloid-β (Aβ) plaque accumulation of 5×FAD transgenic mice by mitigating microglial senescence.

ORGANISM(S): Mus <genus>

SUBMITTER: Gonghua Huang  

PROVIDER: PXD070443 | iProX | Thu Nov 06 00:00:00 GMT 2025

REPOSITORIES: iProX

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